Honouring the best in music videos from the past year, the awards have typically been one of the most outrageous red carpets, and inside is no different.
Whilst on stage talking about Camila she said: "So those of you watching at home, hi Fifth Harmony". During her heartfelt speech, she thanked her manager Benny Medina, mother, children, and fans.
"It's an insane night for me, it's a really special thing - winning this award".
NY rapper Cardi B, 25, made her first public appearance since giving birth to her first child in July.
She also took the opportunity to praise the other women that were nominated.
For the top prize, Cardi B and Mars were competing with Childish Gambino's "This Is America", Drake's "God's Plan", Beyonce and Jay-Z's "Apes-t", Camila Cabello's "Havana" and Ariana Grande's "No Tears Left to Cry".
In 2014, her former band Fifth Harmony were awarded Artist to Watch for Miss Movin' On. When Minaj accepted an award moments later, she looked to Haddish and said, "Don't be coming for Fifth Harmony because Normani is that (chick)".
But that wasn't her only trophy of the night.
Jennifer Lopez brought the audience to its feet with a song and dance medley of her biggest hits as she was presented with the annual Vanguard Award, named after Michael Jackson, recognising her 20 years in show business. "The rapper, best known for the suicide prevention anthem "1-800-273-8255", wore a T-shirt that read, "(Expletive) the wall".