World No. 1 and French Open champion Simona Halep was knocked out of Wimbledon on Saturday, losing to Chinese-Taipei 's Hsieh Su-Wei 3-6, 6-4, 7-5 in the third round.
It is the first time Hsieh, 32, has reached the last 16 of the singles.
"I mean, I'm not surprised anymore", said 2017 French Open champion Ostapenko, a 6-0, 6-4 victor against Vitalia Diatchenko, who eliminated five-time major champion Maria Sharapova in the first round.
"She played incredible, I had to run and fight for every point".
In a sport often dominated by relentless baseline bashers Hsieh brought so much more to the party.
Halep had a match point with Hsieh serving at 4-5 in the third set, but Hsieh fended it off by leaning into a darting backhand down the line.
His next round rival will be Jiri Vesely of Czech Republic.
A thumping forehand of her own from Halep helped tie the set once again, at 3-3, but Hsieh landed the telling blow in the ninth game when Halep found the net to trail again.
The Romanian fears she will not challenge at Wimbledon until she gets to grips with the grass.
It's the first time in the Open era that none of the top five women's seeds have made the last 16 of a Slam.
Meanwhile on Centre Court, three-time champion Novak Djokovic battled back from a set down to defeat Britain's Kyle Edmund 4-6, 6-3, 6-2, 6-4, despite a double-bounce controversy. 'I will not find the excuses about this match, she deserved to win, but still, I'm sad about myself today, ' Halep said.
Van Uytvanck's reward is a date with No. 14 Daria Kasatkina, who stopped No. 17 Ashleigh Barty 7-5, 6-3.
It's the first time in the Open era that none of the top five women's seeds have made the last 16 of a Slam. It's really tough to stay low, to play every ball, to expect actually nothing because you never know where the ball is bouncing and where is coming.
Switzerland's Belinda Bencic continued her return from injury with another fine victory, defeating Spain's world No 26 Carla Suarez Navarro 6-1, 7-6.
Djokovic next plays Russian world number 40 Karen Khachanov.
"On court, I just try to feel free". I am too exhausted.
"There's a shop in London very famous now, called Burger & Lobster", she said.