Israeli troops killed four Palestinians and wounded hundreds of others on Friday with live fire and tear gas used against protesters at the Gaza border, medics said. It said at one location at least two Palestinian militants fired guns at its forces and others threw grenades.
Palestinians say the protests are a popular outpouring of rage against Israel by people demanding the right to return to homes their families fled or were driven from on Israel's founding 70 years ago.
A protester uses a racket to hit back a tear gas canister across a barbed-wire fence during clashes with Israeli forces.
This demonstration came on the last Friday of the Muslim holy month of Ramadan and coincided with Jerusalem Day, an annual anti-Israel protest in Iran.
Israel has lost swathes of farmland and forests on its side of the border to blazes set by coal, or fuel-laden Palestinian kites.
At least 129 Palestinians have been killed by Israeli fire since protests broke out along the Gaza border on March 30. The overwhelming majority of the dead and wounded had been unarmed, according to Gaza health officials.
According to Israeli Defence Minister Avigdor Lieberman, of the more than 600 kites launched from Gaza so far, around 400 kites have been intercepted. From there, smaller groups walked closer to it.
Palestinian protesters run for cover as smoke billows from burning tyres.
The sports-crazed nation of Israel was in uproar on Wednesday over Argentina's abrupt cancellation of a World Cup warm-up match following pro-Palestinian protests, with some of the country's leaders accusing Lionel Messi and his teammates of caving to terrorism.
The encounter was called off on Tuesday after a campaign by the Palestinians following its relocation to Jerusalem.
This is one of the weekly protests by the Palestinians that commemorate Naksa Day ("day of the setback"), when Palestinians were expelled from West Bank and Gaza Strip during the 1948 and 1967 wars with Israel.
Al-Quds day was observed throughout the country on Friday.
He also called on Palestinian demonstrators to "redouble their efforts to get through the rallies without losses and refrain from giving the Israelis a pretext to attack".
Under the hashtag #NothingFriendly campaigners highlighted Israel's human rights abuses and wanton killing of Palestinian demonstrators. They pledged to continue raising voice for rights of oppressed Palestinians and rejecting nefarious designs of Israel and United States against people in various parts of the world including Palestine.
Carrying banners and placards, the participants demanded strong action to save Palestinian children, women and men.
"The International Quds Day marks opposition to occupation, bullying and genocide against the oppressed people of Palestine and opposition to evil powers", the statement said.