Emery has succeeded Arsene Wenger, who left Arsenal after 22 years in charge.
And the key fixtures remain the first that demand the attention, with the titanic battles between the main title challengers always primed to be pivotal dates in the calendar.
Manchester United have an away trip to Huddersfield for the penultimate game of the campaign and will host newly promoted Cardiff City on the last day of the season.
They had the option of returning to Wembley, where they played all of their 2017-18 home games, or reversing all of their early home fixtures, but Mauricio Pochettino was wary of starting the season with a run of games on the road.
With the release of City's 2018/19 Premier League fixtures, we analyse the stand-out matches and potentially key periods.
Some have predicted a long unbeaten start to the campaign for Manchester United and believe Mourinho's men need to hit the ground running if they have wrestle away the title from local rivals Manchester City next season.
However, despite Mike Ashley blocking all bids for Rafa Benitez targets in terms of new faces in the transfer market, there is already silverware on the way to those Newcastle fans.
Tottenham is scheduled to play Fulham at home on the second weekend but it is still unclear if the match will be at the club's temporary home of Wembley Stadium, which it is using while White Hart Lane is being rebuilt.
The match will also be new Arsenal manager Unai Emery's first in English football's top flight. That hasn't, however, stopped the club preparing our pre-season plans.
It is now all about which of them can navigate their programme best - but none of them will want to be in Arsenal's shoes at the beginning of August.