Pompeo listed a dozen actions the US expects from Iran to avoid or end these sanctions.
Last week, the U.S.
Following President Donald Trump's decision to withdraw the U.S. from the deal, Pompeo said a new framework must ensure that "Iran has no possible path to a nuclear weapon, ever".
Mr Pompeo's speech came after Mr Trump earlier this month infuriated USA allies in Europe by withdrawing from the 2015 deal brokered by Barack Obama, Iran and world powers.
It is Americas hope that our labors toward peace and security will bear fruit for the long-suffering people of Iran, Pompeo said.
Hezbollah made the hit list with the secretary of state also pledged that the USA "will track down Iranian operatives and their Hezbollah proxies operating around the world, and we will crush them".
It must also release all USA citizens missing in Iran or being held on "spurious charges".
The speech did not explicitly call for regime change but Pompeo repeatedly urged the Iranian people not to put up with their leaders, specifically naming President Hassan Rouhani and Foreign Minister Mohammad Javad Zarif.
Several major European companies expressed concern about continuing business with Iran following the USA exit, raising further doubts about the viability of the deal.
British Foreign Secretary Boris Johnson cast doubt that the broad list of objectives can be achieved in "a reasonable time frame", as Pompeo described.
Experts say Pompeo's speech represents a seismic shift in America's policy toward Iran. "One with dubious prospects for success", she said. He threatened that failing to meet them would result in sanctions which would ultimately destroy Iran's economy. It protected the world from an Iranian nuclear bomb, and in return it gave the Iranians some recognisable economic benefits. Given the tense trade relations between Washington and Beijing and China's position of rejecting unilateral sanctions in general, it would be shocking if Beijing would cave to United States sanctions impacting its ongoing purchases of Iranian crude. The secretary of state also warned European businesses who work with Iran in violation of U.S. sanctions that they will be held "to account".
Iran must also declare all of its previous efforts to build a nuclear weapon, Pompeo said, reopening an issue that the UN's International Atomic Energy Agency has already deemed closed.
Pompeo's demand that Tehran stop uranium enrichment goes even further than the nuclear deal. "Any new agreement will make sure Iran never acquires a nuclear weapon and deter the regime's malign behavior in a way that the JCPOA never could".
The Trump administration negotiated for months with Germany, France and the United Kingdom to create a supplement to the Iran agreement.
Richard PompeoPompeo to outline post-deal strategy on Iran Trump asking aides whether he should proceed with North Korea summit: report Venezuela's Maduro set to win in presidential election derided by United States as a "sham" MORE vowed Monday to levy an "unprecedented" level of sanctions on Iran after the USA announced it was withdrawing from the 2015 nuclear accord. The rest members of the plan criticized the Trump decision and said they would keep to the agreement.