"We have irrefutable evidence that this was another staged event, and that the secret services of a certain state that is now at the forefront of a Russophobic campaign was involved in this staged event", he said during a press conference.
The call for action comes after a suspected chemical attack on the rebel-held town of Douma in the Eastern Ghouta on Saturday, which killed dozens of people, according to opposition activists, rescue workers and medics.
The US and its allies believe the Syrian regime was behind the attack, but Russian Federation has long insisted it was staged by rebels in an attempt to provoke further Western intervention.
Russian Federation responded angrily to a USA -led strike against Syria on Friday, warning of unspecified "consequences" that stoked fears the conflict could escalate.
In the near term, the military strike appeared to ramp up a searing war of words between Washington and Moscow, which regarded the action as a attack on Russian Federation itself.
But relations have instead soured over mounting evidence of Russian meddling in the 2016 presidential election, Russia's alleged poisoning of a former double agent in Britain and Putin's support of Assad's government in Syria.
The US president claimed that the joint action was meant to establish a "strong deterrent" against the production, spread, and use of chemical weapons.
"All responsibility for them rests with Washington, London and Paris".
A fact-finding mission from the Organization for the Prohibition of Chemical Weapons is expected to head to Douma, the site of the suspected attack. "I hope no one would dare to launch such an adventure now", Lavrov said.
Speaking about the Skripal poisoning and looming decision over air strikes against the Syrian government, he accused humanitarian groups of staging the chemical attack and blasted the United Kingdom for a lack of "transparency" during the Salisbury investigation.
"The sole thing that they have an interest in is to oust the Syrian government and to deter, contain the Russian Federation", he added.
The Russian military has claimed the chemical attack in Syria was orchestrated by the United Kingdom but has offered no proof.
US Defence Secretary Jim Mattis said the strikes were a "one-time shot" and that no additional airstrikes were now planned.
On Thursday, Russia's military said Douma has been brought under full control of the Syrian government under a Russia-mediated deal that secured the evacuation of the rebels and thousands of civilians after it was recaptured by Syrian forces.