The midfielder missed Saturday's 2-1 home Premier League win over Liverpool after sustaining a thigh injury.
The last-16 tie is delicately balanced at 0-0 after Mourinho resorted to type by concentrating on obtaining a clean sheet at the Ramon Sanchez Pizjuan three weeks ago.
"When you are in the last 16 it looks really, really far [away] but when the team gets in the last eight you start smelling semi-finals".
'I don't know what Real Madrid's intentions are, but if I were them, I would think of another player'.
Mourinho led Porto to an unlikely triumph in the 2003-04 competition and did likewise with Inter six years later.
Had Alexis Sanchez made a better fist of things in the No 10 role, United might have had even more to show for their solid midfield and defensive foundations, in which the return of centre-half Eric Bailly helped to draw outstanding performances from Chris Smalling and Ashley Young.
However, if Conte plays the same way as he did at Manchester City, which I think he might, they will have no joy because they'll fail to get out of their own half again.
Lionel Messi had a nice rest at the weekend to be ready for this one, so I don't give Chelsea much hope at all.
Ukraine's Brazilian-born sensation Marlos has starred for Shakhtar Donetsk on a Champions League run that could see them reach the quarter-finals for only the second time when they go to Roma.
"After that, we tried to defend our advantage, which we managed to do".
Asked after the win over Liverpool if Pogba would be available for Sevilla, manager Jose Mourinho said: "I don't know".
He also cited Sevilla's group-stage draws against Jurgen Klopp's men as a sign of their quality.
"Very important", defensive midfielder Matic said of the Liverpool win.
At the same time, it has to be remembered that Sevilla were the team disappointed with the fact that the first leg ended goalless.
Strikers Zlatan Ibrahimovic and Anthony Martial did take part, but Marcos Rojo, Phil Jones, Daley Blind and Ander Herrera were missing.
However, there was better news regarding the fitness of Anthony Martial as the French global returned to full training today and has been passed fit to take on Sevilla tomorrow night which will be a big boost for the Red Devils.