Following recent news of "crisis talks" between the couple, it's been decided that Ant will split from his wife of 11 years.
Both Ant and Lisa have asked for respect and privacy during this harrowing time.
"No further statement will be made".
'It hasn't happened overnight.
The 42-year-old I'm A Celebrity presenter has overhauled his life since going into rehab last June, where he underwent treatment for an addiction to prescription drugs and alcohol.
And his health was reportedly a factor in Ant's decision to divorce Lisa, whom he has been with for 23 years and married in 2006.
After exiting rehab in August, he chose to live into a rented home in west London a few streets away from their marital home.
A source close to the ITV star said the pair had tried hard to mend the relationship but in the end Ant made the decision to end the marriage.
McPartlin entered rehab last summer and a source told the newspaper that his marriage had "effectively been struggling for eight months".
They've met up and spoken about it a number of times and this is the decision he has made. They've been having problems for ages. Her fans were quick to offer their support, with one tweeting: "Lots of hugs from a complete stranger (me) but heartfelt", while another added: "Sending you hugs sweetheart - even in the darkest of situations you always need to find the positives".
When Lisa was accused of "throwing [her] marriage away" previous year by a Twitter troll, Lisa replied: "Educate yourself first, love, and get your facts rights".
"But she is gradually realising that as far as he is concerned, there's no way back".