The strike began at 8 a.m. (0600 GMT/UTC) and affected airports, shipping ports, hospitals, banks and government offices.
Teva employees also protest at Ashdod facility.
The strike, set to end at noon, halted operations at Israel's main worldwide airport and seaports on Sunday morning.
In his opening remarks to the weekly cabinet meeting on Sunday, Prime Minister Binyamin Netanyahu added, "This week I will meet - along with the Finance Minister and the Economy Minister - with the CEO of Teva". Last week, the chairman of Israel's Securities Authority said it will not allow companies whose value is dependent on the bitcoin to be included in the indices of the Tel Aviv Stock exchange. "The second thing is of course to do everything to prevent the closure of factories in Jerusalem".
"It started as an Israeli company and we want it to remain as an Israeli company", Netanyahu said.
Teva Pharmaceutical Industries, the world's largest producer of generic drugs, has said its reductions would be across-the-board and in all its locations.
Nissenkorn said Saturday evening the strike is meant to send a "clear message" the union would not accept the layoffs of Israeli workers. "Organized labor has been enlisted and is sending a clear message". The generic drugs powerhouse is now carrying a $34.7 billion debt-a result of a $40.5 acquisition of Actavis.
The acquisition has been accompanied by low prices for generics, particularly in the United States, a major market.
Teva is expected to provide its 2018 outlook in February, and will give a longer-term strategic plan for the company later that year.
The 2-year restructuring plan aims to cut Teva's costs by $3 billion by the end of 2019, from an estimated base of $16.1 billion, according to Fierce Biotech.