Chelsea have won the Premier League title in two of the past three seasons to dominate the English top flight. So United, City and Spurs know they will be up against teams who finished second. Real Madrid are also confirmed to finish second and will be joined by three more sides - now scheduled to be Sevilla, Shakhtar Donetsk and Porto.
Captain Gary Cahill has admitted Chelsea would rather avoid Barcelona and Paris St Germain in the first knock-out round of the Champions League.
Are there any other restrictions?
However, teams from the same groups can not face each other, while teams from the same country can not take on one another either.
Cesc Fabregas is prepared to face former club Barcelona in the next round of the Champions League and says Chelsea don't fear anyone.
Barcelona, Paris Saint-Germain and Besiktas are amongst the opposition that Chelsea can face, but Azpilicueta isn't too anxious about his side's second-placed finish. Bayern Munich, Juventus, Sevilla, Shakhtar Donetsk, Porto, Real Madrid. will all be on the cards when the group 16 drawing takes place December 11.
Manchester United: Bayern Munich, FC Porto, Juventus, Real Madrid, Sevilla, Shakhtar Donetsk. However, these rules will not be applicable to the quarter-final stages and onwards.
Since the Champions League reverted back to a one group stage format for the 2003-04 season, the Premier League has been allocated four Champions League places, but only on six occasions in the previous 14 years has a full complement of English teams succeeded in qualifying for the next stage.
When is the draw and when are the games?
English teams will not be able to be meet in Monday's draw, under UEFA regulations.
The first legs will take place on February 13, 14, 20 and 21.